Considering the many ways these games can screw you over, what's YOUR most hated way? Mine is to get fucked against a wall, e.g., one or more enemies slashing away at me and I can't escape due to a wall or some stupid obstacle. Note that these options are mostly enemy-based rather than boss-based, because sometimes the regular enemies interact with the level design in perfectly horrible ways that boss arenas tend to avoid (except capra demon of course, fuck that guy)
Your vote: Fucked against a wall