Ive been redoing my UI and cleaning up my keybinds. I have used a 12-button mouse for a long time. I think I started in Cata, but am not sure. Its been a while. Anyway, I was thinking of swapping to a 2-button mouse. So, the obvious change would be from mainly using abilities on the mouse vs using them on the keyboard. Personally, I feel like using them on the mouse gives you an advantage because you can still keyboard move and hit abilities on the mouse. But, maybe Im wrong. With the 2-button mouse. I would make one Alt and one Ctrl and then mainly use the keyboard for abilities. Just checking to see what most people are doing and if you have tried both and which you prefer.